• EBI is known to play a critical role

  2019-08-08

  

  EBI2 is known to play a critical role in the induction of antibody responses in secondary lymphoid tissues.13, 14 However, little is known about the expression and function of EBI2 in human peripheral tissues. To our knowledge, this is the first report of increased EBI2 levels in peripheral tissues

• Chemokine receptor expression in MCL is shown

  2019-08-08

  

  Chemokine receptor expression in MCL is shown in Table 1. CXCR4, CXCR5 and CCR6 protein was detected in the majority of patients [10], [72], [102], [118] and CX3CR1 was found to be present in up to 75% of cases depending on the method used to identify the receptor [103]. CCR7 was more highly express

• br Conflicts of interest br Financial

  2019-08-08

  

  Conflicts of interest Financial support NZ is an Established Investigator of the Dutch Heart Foundation (2013T111) and is supported by an ERC Consolidator grant (617376) from the European Research Council and by a Vici grant from the Netherlands Organization for Scientific Research (NWO; 91818

• Acknowledgements This work was supported in

  2019-08-07

  Acknowledgements This work was supported in part by a Scholarship Fund for Young Researchers by the Promotion and Mutual Aid Corporation for Private (2017 to S.K.), research grant from Japan Rett Syndrome Support Organization (2018 to S.K.), and MEXT-Supported Program for the Strategic Research Foundation at Private Universities (2015–2019 to T.I.).

• One step in pyrimidine biosynthesis is conversion of l

  2019-08-06

  One step in pyrimidine biosynthesis is conversion of l-dihydroorotate (DHO) to orotate (ORO), under action of the enzyme dihydroorotate dehydrogenase (DHODH, EC 1.3.99.11), which contains a flavine (FMN) as redox cofactor [1].

• Materials and methods Results Assay of botulinum toxin acti

  2019-08-05

  Materials and methods Results Assay of botulinum toxin activity is critical for the risk-assessment, diagnosis, and treatment of botulism cases.

• Investigations of mice lacking up to three CDKs identified

  2019-08-02

  Investigations of mice lacking up to three CDKs identified the mitosis-regulating kinase CDK1 as the main essential component for the cell cycle, whereas ablation of other T0901317 regulators such as CDK2, CDK4, or CDK6 did not result in defective proliferation 12, 13.

• Materials and methods Results Discussion Anti

  2019-08-01

  Materials and methods Results Discussion Anti-EGFR therapy for epithelial carcinomas has important clinical significance, but widespread intrinsic or acquired resistance seriously affects efficacy.

• DSBs can be repaired by two

  2019-07-31

  DSBs can be repaired by two major pathways: canonical non-homologous end-joining (c-NHEJ) and homologous recombination (HR) (Chapman et al., 2012).

• Materials and methods Results Discussion Recently it

  2019-07-30

  Materials and methods Results Discussion Recently it has been found that prostaglandins play an important role in modulating the host immune system [1,3,22,23], and some parasites produce these eicosanoid mediators to survive into their hosts [6,[10], [11], [12],24,25].

• Several mechanisms are implicated in lipid induced insulin r

  2019-07-27

  Several mechanisms are implicated in lipid-induced insulin resistance in muscle, including oxidative stress (Koves et al., 2008, Zhang et al., 2011, Muoio and Neufer, 2012).

• We found that Th cells derived either from in

  2019-07-26

  We found that Th17 cells, derived either from in vivo immunization or in vitro polarization under pathogenic conditions (in presence of IL-23 and/or IL-1β) expressed high levels of EBI2.

• Therefore the SPH algorithm in AUTODYN D was

  2019-07-25

  Therefore, the SPH algorithm in AUTODYN-3D™ was used to simulate the experiment in Ref. [5] to verify the credibility of the numerical simulation method by results that could be measured accurately.

• Table gives the list of components which will be modeled

  2019-07-24

  Table 1 gives the list of components which will be modeled.

• Autoradiography studies have shown cerebellum to be devoid

  2019-07-23

  Autoradiography studies have shown AMI-1 to be devoid of D1-R [40], confirming that this region may serve as reference for estimation of free and non-specifically bound radioligand concentration in tissue (= non-displaceable uptake).

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