Materials and methods Results Discussion Anti

2019-08-01

Materials and methods Results Discussion Anti-EGFR therapy for epithelial carcinomas has important clinical significance, but widespread intrinsic or acquired resistance seriously affects efficacy.

DSBs can be repaired by two

2019-07-31

DSBs can be repaired by two major pathways: canonical non-homologous end-joining (c-NHEJ) and homologous recombination (HR) (Chapman et al., 2012).

Materials and methods Results Discussion Recently it

2019-07-30

Materials and methods Results Discussion Recently it has been found that prostaglandins play an important role in modulating the host immune system [1,3,22,23], and some parasites produce these eicosanoid mediators to survive into their hosts [6,[10], [11], [12],24,25].

Several mechanisms are implicated in lipid induced insulin r

2019-07-27

Several mechanisms are implicated in lipid-induced insulin resistance in muscle, including oxidative stress (Koves et al., 2008, Zhang et al., 2011, Muoio and Neufer, 2012).

We found that Th cells derived either from in

2019-07-26

We found that Th17 cells, derived either from in vivo immunization or in vitro polarization under pathogenic conditions (in presence of IL-23 and/or IL-1β) expressed high levels of EBI2.

Therefore the SPH algorithm in AUTODYN D was

2019-07-25

Therefore, the SPH algorithm in AUTODYN-3D™ was used to simulate the experiment in Ref. [5] to verify the credibility of the numerical simulation method by results that could be measured accurately.

Table gives the list of components which will be modeled

2019-07-24

Table 1 gives the list of components which will be modeled.

Autoradiography studies have shown cerebellum to be devoid

2019-07-23

Autoradiography studies have shown AMI-1 to be devoid of D1-R [40], confirming that this region may serve as reference for estimation of free and non-specifically bound radioligand concentration in tissue (= non-displaceable uptake).

Methods Results IAA

2019-07-22

Methods Results IAA-94 abrogated the protective effects of IPC as it increased myocardial infarction (MI) due to IR injury in vitro (Diaz et al., 1999), and also prevented cyclosporine A mediated cardioprotection (Diaz et al., 2013).

Conclusion The preclinical data reported in this

2019-07-19

Conclusion The preclinical data reported in this study shows that LAS191859 is a potent and safe CRTh2 antagonist, with a long receptor residence time that provides a sustained in vivo efficacy.

Mammalian cells contain significant amounts

2019-07-18

Mammalian cells contain significant amounts of a relatively lesser known enzyme that shows marked specifity for ether lipids containing AA and other 20–22 carbon fatty acids.

Nitric oxide NO is synthesized by conversion of the

2019-07-17

Nitric oxide (NO) is synthesized by conversion of the l-arginine to NO and l-citrulline through reaction which is catalyzed by nitric oxide synthetase (NOS) (Knowles and Moncada, 1994).

As small non coding RNAs

2019-07-16

As small non-coding RNAs, microRNAs (miRNAs) can control gene expression at the post-transcriptional level by binding to the 3′-untranslated regions (3′-UTR) of messenger RNAs (mRNA) [15], [16]. miRNAs have been anticipated to regulate virtually all cellular mechanisms [17] and to play an important role in cellular responses, including cell proliferation, apoptosis and differentiation [18], [19].

Effects of estrogen on vascular function

2019-07-15

Effects of estrogen on vascular function Atherosclerosis is a chronic inflammatory condition of the vascular wall (Figure 1) that can be converted to an acute clinical event by the induction of plaque rupture or erosion, leading to thrombosis [58].

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2018-07-29