• Investigations of mice lacking up to three CDKs identified

  2019-08-02

  Investigations of mice lacking up to three CDKs identified the mitosis-regulating kinase CDK1 as the main essential component for the cell cycle, whereas ablation of other T0901317 regulators such as CDK2, CDK4, or CDK6 did not result in defective proliferation 12, 13.

• Materials and methods Results Discussion Anti

  2019-08-01

  Materials and methods Results Discussion Anti-EGFR therapy for epithelial carcinomas has important clinical significance, but widespread intrinsic or acquired resistance seriously affects efficacy.

• DSBs can be repaired by two

  2019-07-31

  DSBs can be repaired by two major pathways: canonical non-homologous end-joining (c-NHEJ) and homologous recombination (HR) (Chapman et al., 2012).

• Materials and methods Results Discussion Recently it

  2019-07-30

  Materials and methods Results Discussion Recently it has been found that prostaglandins play an important role in modulating the host immune system [1,3,22,23], and some parasites produce these eicosanoid mediators to survive into their hosts [6,[10], [11], [12],24,25].

• Several mechanisms are implicated in lipid induced insulin r

  2019-07-27

  Several mechanisms are implicated in lipid-induced insulin resistance in muscle, including oxidative stress (Koves et al., 2008, Zhang et al., 2011, Muoio and Neufer, 2012).

• We found that Th cells derived either from in

  2019-07-26

  We found that Th17 cells, derived either from in vivo immunization or in vitro polarization under pathogenic conditions (in presence of IL-23 and/or IL-1β) expressed high levels of EBI2.

• Therefore the SPH algorithm in AUTODYN D was

  2019-07-25

  Therefore, the SPH algorithm in AUTODYN-3D™ was used to simulate the experiment in Ref. [5] to verify the credibility of the numerical simulation method by results that could be measured accurately.

• Table gives the list of components which will be modeled

  2019-07-24

  Table 1 gives the list of components which will be modeled.

• Autoradiography studies have shown cerebellum to be devoid

  2019-07-23

  Autoradiography studies have shown AMI-1 to be devoid of D1-R [40], confirming that this region may serve as reference for estimation of free and non-specifically bound radioligand concentration in tissue (= non-displaceable uptake).

• Methods Results IAA

  2019-07-22

  Methods Results IAA-94 abrogated the protective effects of IPC as it increased myocardial infarction (MI) due to IR injury in vitro (Diaz et al., 1999), and also prevented cyclosporine A mediated cardioprotection (Diaz et al., 2013).

• Conclusion The preclinical data reported in this

  2019-07-19

  Conclusion The preclinical data reported in this study shows that LAS191859 is a potent and safe CRTh2 antagonist, with a long receptor residence time that provides a sustained in vivo efficacy.

• Mammalian cells contain significant amounts

  2019-07-18

  Mammalian cells contain significant amounts of a relatively lesser known enzyme that shows marked specifity for ether lipids containing AA and other 20–22 carbon fatty acids.

• Nitric oxide NO is synthesized by conversion of the

  2019-07-17

  Nitric oxide (NO) is synthesized by conversion of the l-arginine to NO and l-citrulline through reaction which is catalyzed by nitric oxide synthetase (NOS) (Knowles and Moncada, 1994).

• As small non coding RNAs

  2019-07-16

  As small non-coding RNAs, microRNAs (miRNAs) can control gene expression at the post-transcriptional level by binding to the 3′-untranslated regions (3′-UTR) of messenger RNAs (mRNA) [15], [16]. miRNAs have been anticipated to regulate virtually all cellular mechanisms [17] and to play an important role in cellular responses, including cell proliferation, apoptosis and differentiation [18], [19].

• Effects of estrogen on vascular function

  2019-07-15

  Effects of estrogen on vascular function Atherosclerosis is a chronic inflammatory condition of the vascular wall (Figure 1) that can be converted to an acute clinical event by the induction of plaque rupture or erosion, leading to thrombosis [58].

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