• Introduction DHFR is an important enzyme

  2019-11-12

  

  Introduction DHFR is an important enzyme in both mammals and microorganism including Mycobacterium tuberculosis (Mtb). It catalyzes folic RF 9 conversion to dihydro and tetrahydro folic acid which is a crucial step in folate pathway [1]. Inhibition of folate pathway leads to interruption of thymidi

• The objective of the present study was

  2019-11-12

  

  The objective of the present study was to investigate the role of the CRF system in the neuroadaptations associated with nicotine dependence. To this aim, the regulation of the gene expression of CRF and its receptors was assessed in g 15 mg regions belonging to the reward pathway using a model of n

• Pahlavanzadeh and Fakouri Baygi employed PC SAFT

  2019-11-12

  

  Pahlavanzadeh and Fakouri-Baygi [6] employed PC-SAFT EoS to predict the PSB 0777 ammonium salt synthesis of carbon dioxide by aqueous MEA solutions. They used the ideal form of Smith–Missen algorithm to calculate liquid phase concentrations. The results illustrate acceptable accuracies so that the

• The CYP A genes are regulated physiologically by glucocortic

  2019-11-11

  

  The CYP3A genes are regulated physiologically by glucocorticosteroids, growth hormone, thyroid hormones and cytokines [13, 20, 30]. It has been shown that glucocorticoid receptor (GR), pregnane X receptor (PXR), constitutive androstane receptor (CAR) and vitamin D receptor (VDR) play an important ro

• br Conclusion In vivo pharmacokinetic studies showed that da

  2019-11-11

  

  Conclusion In vivo pharmacokinetic studies showed that dasatinib monohydrate pretreatment significantly decreased the blood level of CsA in rats, which was most probably due to the induction of CYP3A2 isoenzymes. The nilotinib pre-treatment had no significant effects on cyclosporine pharmacokinet

• br Transparency document br Acknowledgments This work

  2019-11-11

  

  Transparency document Acknowledgments This work was supported by the Ministry of Education, Youth and Sports of the Czech Republic (the National Program of Sustainability I, Grants LO1204 and LO1304), by the Czech Science Foundation (15-17282Y) and by Palacký University Olomouc (IGA_PrF_2017_0

• In summary our present work

  2019-11-11

  

  In summary, our present work establishes the ability of the mammalian intestine to function as an environmental sensor able to retain an active metabolic memory for early postnatal nutritional conditions. Epigenetic silencing of the expression of the main cholesterol TG003 transporter Npc1l1 concei

• Gupta et al have shown

  2019-11-11

  

  Gupta et al have shown that a genetic variant associated with the 5 vascular diseases (coronary artery disease, migraine, carotid artery dissection, fibro-muscular dysplasia, and hypertension) is a distal regulator of the ET-1 gene [30]. They found that a single nucleotide polymorphism (SNP) located

• Based on the SUMO SIM interaction involved in SUMOD

  2019-11-11

  

  Based on the SUMO–SIM interaction involved in SUMOD positioning, a SUMO2ΔSBD (SIM-binding domain; Q30A, F31A, I33A) mutant can be investigated that disrupts this important binding interface (Eisenhardt et al., 2015; Meulmeester, Kunze, Hsiao, Urlaub, & Melchior, 2008). In Fig. 4A, multiturnover assa

• In Senegal malaria remains a formidable public health issue

  2019-11-11

  

  In Senegal, malaria remains a formidable public health issue, causing significant morbidity and mortality in infants and pregnant women (WHO Malaria Report, 2012). In the absence of an effective vaccine, the National Malaria Control Program has followed WHO recommendations for IPTp-SP since 2003. Th

• As compared with the broad spectrum of chemicals known to

  2019-11-11

  

  As compared with the broad spectrum of chemicals known to serve as the ligands for PXR and CAR, the ligands of VDR are previously restricted to VD3 as well as its hydroxylated metabolites and the secondary bile ampa receptor LCA. Recently, the VDR-binding capacities of more compounds have been disc

• br Nuclear export and the functions of CRM The nuclear

  2019-11-11

  

  Nuclear export and the functions of CRM1 The nuclear envelope provides a compartmentalized intracellular environment for DNA replication, the synthesis of RNA, and production of ribosomes, and, as such, it can regulate cellular biological processes including apoptosis and proliferation. Nucleocyt

• Pattern separation is a process that takes

  2019-11-11

  

  Pattern separation is a process that takes place in the hippocampus and more specifically in the dentate gyrus (DG) and Cornu Ammonis region 3 (CA3) (Morris, Churchwell, Kesner, & Gilbert, 2012). The main source of input in the hippocampus is derived from the enthorinal cortex (EC) that mainly proje

• In general graphene nanoplatelets have many

  2019-11-08

  

  In general, graphene nanoplatelets have many useful features for the design of multifunctional composite materials, including excellent electrical and thermal conductivities, considerable weight-saving lightness, and high mechanical strength [26]. Moreover, they are characterized by a high specific

• In glioblastoma methylation of pMGMT is predictive of the ef

  2019-11-08

  

  In glioblastoma, methylation of pMGMT is predictive of the efficacy of temozolomide with an increased survival [22], [23], [24], [25]. As in glioblastoma [24], [26], [27], [28], pMGMT methylation assessed by pyrosequencing (with immunochemistry, IHC) is the most effective and reproducible technique

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