• The absence of differences between GalR knockout and

  2021-11-26

  

  The absence of differences between GalR1 knockout and wild type mice in kainic acid-induced seizures suggests that GalR1 do not interfere with the seizure-inducing action of kainic acid. Postsynaptic kainate receptors are excitatory ionotropic glutamate receptors and their activation leads to seizur

• RDL is of interest as it is the target of

  2021-11-26

  

  RDL is of interest as it is the target of highly effective insecticides (Buckingham et al., 2005, Raymond-Delpech et al., 2005). Point mutations, particularly an alanine to serine or glycine mutation in TM2, underlie resistance to several insecticides, including dieldrin, picrotoxinin and fipronil (

• We identified three genes KEAP NAA

  2021-11-26

  

  We identified three genes—KEAP1, NAA38, and ABCC1/MRP1—as negative regulators of glutathione abundance in human cells. Like KEAP1, NAA38 appears to regulate NRF2 stability, as NAA38 deletion increased NRF2 protein levels and the expression of NRF2 target genes. NAA38 is a component of the NatC N-ter

• br Promotion of GLS expression Glutamine metabolism is anoth

  2021-11-26

  

  Promotion of GLS2 expression Glutamine metabolism is another target for alteration in ferroptosis. Glutamine is required for the induction of ferroptosis during serum-induced injury after amino Urea starvation [72]. The first step of glutamine catabolism is its conversion to glutamate, which is

• We also wonder what function

  2021-11-26

  

  We also wonder what function(s) both FPPS1 and FPPS2 genes had in leaf. As some research indicated that the alpha-farnesene was also detected in ripe leaf of crabapple (Malus sp.) (Wu et al., 2012), one or both of them may be related to the synthesis of alpha-farnesene in leaf. To our knowledge, the

• Endotoxin induced pulmonary hypertension is a reproducible f

  2021-11-26

  

  Endotoxin induced-pulmonary glutathione reductase is a reproducible finding in various animal models Leeper-Woodford et al., 1991, Weitzberg et al., 1993 and is also a feature of human sepsis where it may affect right ventricular function (Vincent, 1998). Mechanisms such as vasoconstriction and leuk

• Experimental conditions may be critical to explain one

  2021-11-26

  

  Experimental conditions may be critical to explain one model or the other. The matter of Hippo-driven cytoplasmic sequestration (Varelas et al., 2008) of active SMAD complexes (Varelas et al., 2008) vs. TßR basolateral relocalization upon epithelial polarization (Nallet-Staub et al., 2015) as mechan

• elastase Human epidermal growth factor receptor HER neu also

  2021-11-26

  

  Human epidermal growth factor receptor 2 (HER2/neu, also known as CerbB-2, or ERBB-2) is a proto-oncogene located on chromosome 17q21, which encodes a transmembrane protein with tyrosine kinase activity, and belongs to the HER receptor family (EGFR, named also HER1, HER3, and HER4) [6]. HER2 is invo

• Earlier we have shown relationship between cytotoxicity and

  2021-11-26

  

  Earlier, we have shown relationship between cytotoxicity and receptor degeneration in ptc124 having specific neurotransmitter receptors (Siddiqui et al., 2008). In the present study, exposure to 4-HNE reduced expression of DA-D2 receptors in PC12 cells which was found to be concentration dependent a

• br Acknowledgments This research was supported by the

  2021-11-26

  

  Acknowledgments This research was supported by the Czech Ministry of Education, Youth and Sports by grants MSM LH11013 and Czech Grant Agency (501/12/0590). David Kopečný and Martina Kopečná were supported by the grant LO1204 from the National Program of Sustainability I by the Ministry of Educat

• In this study we describe the role of a

  2021-11-26

  

  In this study, we describe the role of a specific species of LPI in the secretion of GLP-1 from enteroendocrine L-cells and primary cell preparations. We further demonstrate the specific role of GPR119 in LPI-dependent GLP-1 secretion. To achieve this, we downregulated GPR119 and GPR55 protein expre

• br Results and discussion br

  2021-11-25

  

  Results and discussion Conclusions TZDs represent a well-studied group of antidiabetic agents. Based on previous observations of the ability of some TZDs to activate FFAR1, we designed five scaffolds consisting of the TZD head, a linker, and a carefully selected privileged structure. For the p

• Sumatriptan br Experimental br Acknowledgments This project

  2021-11-25

  

  Experimental Acknowledgments This project was generously supported by Grünenthal GmbH and IECB. We also thank the staff members of the technical platform of IECB and Grünenthal GmbH for their availability and their skills. Introduction Glucocorticoids (GCs) are essential steroid hormones t

• Glucose metabolic pathways are well defined but the subcellu

  2021-11-25

  

  Glucose metabolic pathways are well defined but the subcellular organization of these pathways is poorly understood in liver and kidney. Several factors affect the net flux of gluconeogenesis and allow the ras gtpase to respond to physiological changes [1]. Ovadi and Srere have suggested that a new

• The ETB receptor has been shown to

  2021-11-25

  

  The ETB receptor has been shown to decrease sodium transport in the renal medullary collecting duct and medullary thick ascending limb of Henle10, 11, 12, 13, 18. However, both inhibitory and stimulatory effects of endothelin have been reported in the proximal tubule16, 47, 48, 49. In the rat, endot

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