• br GSNOR regulates SA synthesis and SA

  2021-12-18

  

  GSNOR1 regulates SA synthesis and SA signalling The phenolic metabolite salicylic pretomanid (SA) is a powerful immune activator in plants. Moreover, mutations that disable SA biosynthesis or transgenes that result in its depletion compromise both resistance (R) gene-mediated and basal resistance

• Glycogen synthase kinase GSK is currently

  2021-12-18

  

  Glycogen synthase kinase 3 (GSK3) is currently considered to be a multifunctional serine/threonine kinase involved in a wide spectrum of cellular processes such as glycogen metabolism, cell proliferation, neuronal function, oncogenesis or embryonic development (for recent reviews see: Rayasam et al.

• TG101348 No other lacZ mutant showed a marked difference in

  2021-12-18

  

  No other lacZ mutant showed a marked difference in mutation rate between fpg and fpg backgrounds (that is, rates were comparable between HS101 and CSH1191, HS102 and CSH1192, etc.). The number of reversion mutants was much higher in HS1194 than in any other fpg strain. The inclusion of the pTRC99a p

• Although side effects as paresthesia due to

  2021-12-18

  

  Although side effects as paresthesia due to the application of β-alanine are known, a study in 2006 pointed out that there are no clinical (biochemical or hematological) changes after a long-term supplementation with β-alanine. In 2015, the International Society of Sports Nutrition rejected any argu

• Boswellia papyrifera Del Hochst mostly grows in Sudanian

  2021-12-18

  

  Boswellia papyrifera (Del.) Hochst., mostly grows in Sudanian and Sahelian regions and their oleo-gum resin is used medically in treatment of rheumatism, menorrhagia, amenorrhoea, vaginal infections, ulcers, sores, polyuria, syphilis, bronchitis, scrofulous affections, inflammations, asthma, diarrhe

• In this study an galactosidase

  2021-12-17

  

  In this study, an α-galactosidase gene, GalA, from a Aspergillus oryzae strain RIB40 [14] was artificially synthesized. To produce high levels of secretory expression in Pichia and facilitate its industrial application, we systematically investigated the gene dosages and the role of the ERSAs, namel

• Carmustine Data are expressed as means

  2021-12-17

  

  Data are expressed as means±SE. Statistical significance was determined by the Student's -test or ANOVA with post hoc Bonferroni test. A value of Carmustine expressing human FPPS. Western blot analysis showed a clear band, which indicated the overexpression of FPPS, in U87MG cells (A, insert). Expos

• Anti apoptotic Bcl proteins have become attractive targets f

  2021-12-17

  

  Anti-apoptotic Bcl-2 proteins have become attractive targets for anti-cancer agents development, because they are associated with progression of a wide variety of human cancers., , The small-molecular Bcl-2 inhibitor venetoclax (ABT-199) () has been approved recently for the treatment of patients w

• Carbon monoxide another key product

  2021-12-17

  

  Carbon monoxide, another key product from the breakdown of heme by HO-1, also plays an important role in the vasculature. Like NO, CO is endogenously derived from the endothelium [68] and can weakly activate sGC by binding to its heme moiety [69]. CO was found to have vasodepressor activity in rats

• br Cholecystokinin CCK CCK is secreted by enteroendocrine I

  2021-12-17

  

  Cholecystokinin (CCK) CCK is secreted by enteroendocrine I-cells of the duodenum and jejunum in response to amino acids and lipids [14]. There are two forms of the CCK receptor, CCK1 which is expressed on pancreatic α- and β-cells while CCK2 is located on somatostatin-secreting δ-cells [8]. CCK r

• Among prostaglandins PG PGD remained

  2021-12-17

  

  Among prostaglandins (PG), PGD2 remained the most elusive species for a long time and was initially regarded as having negligible biological activity [1]. In 1974 its inhibitory effect on platelet aggregation was discovered by Smith et al. [2] and Mills & McFarlain [3], and both pressor and depress

• Little is known about the role of GPR in

  2021-12-17

  

  Little is known about the role of GPR35 in physiology and pathology. Using GPR35 knockout and wild-type mice showed that GPR35 activation by KYNA improves energy metabolism and inflammation, while demonstrated that GPR35 plays an important role in the development of angiotensin II-induced hyperten

• br Significant efforts are currently focused on non

  2021-12-17

  

  Significant efforts are currently focused on non-dopaminergic strategies to address the unmet medical needs in schizophrenia, and targeting -methyl--aspartate (NMDA) Altretamine hypofunction has garnered a great deal of attention., , Elevation of synaptic glycine levels near NMDA-containing syna

• br STAR Methods br Introduction

  2021-12-17

  

  STAR★Methods Introduction Glycosylation is one of the most prevalent post-translational modifications of proteins. It not only plays major roles in folding, transport and localization of proteins [1], but also regulates various biological processes such as cell growth, viral replication and im

• br Conclusion These are exciting times in EAAT

  2021-12-17

  

  Conclusion These are exciting times in EAAT research. The discovery and use of the GltPh and GltTk transporters as model systems for EAATs has provided detailed understanding of structure–function aspects of the transporters. Moreover, recent studies into the physiological functions of the trans

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