• The C terminal regions in both FGF and FGF

  2022-04-07

  

  The C-terminal regions in both FGF19 and FGF21 define their KLB interaction [15], [16], [23], [25]. However, less than 40% identity in comparative alignment of C-terminal sequences for these two proteins (Table 1) suggests that their interaction with KLB may require higher-order association with oth

• Ning et al showed that

  2022-04-07

  

  Ning et al. showed that LPC 18:1 appeared to increase insulin release through both GPR119-dependent and -independent mechanisms (Ning et al., 2008). In our study, we have shown that not only GPR119 but also GPR40 and GPR55 participate in LPC-stimulated insulin secretion (Fig. 4, Fig. 5) and target p

• br Results and discussion CATALYST software allows automatic

  2022-04-07

  

  Results and discussion CATALYST software allows automatic pharmacophore construction by using a collection of molecules with activities ranging over a number of orders of magnitude. In addition, CATALYST pharmacophores (hypotheses) explain the variability of bioactivity with respect to the geomet

• HCC metastasis is a multistep multifactorial process includi

  2022-04-07

  

  HCC metastasis is a multistep, multifactorial process, including adhesion of tumor butein to the extracellular matrix (ECM), remodeling and degradation of ECM, invasion through local tissue, intravasation into blood or lymph vessels, and forming new tumors at distant sites [6,7]. Loss of adhesion o

• Apoptosis is one of critical toxic mechanisms

  2022-04-07

  

  Apoptosis is one of critical toxic mechanisms of benzene metabolites. In this work, overexpression of HIF-1a could significantly reduce the increase in cell apoptosis caused by 40 μM BQ. At the meanwhile, anti-apoptotic protein Bcl-2 level was significantly elevated in HIF-1a overexpression cells th

• In humans polymorphisms in the

  2022-04-07

  

  In humans, polymorphisms in the lengths of GT sequences (from 11 to 40) within the HMOX1 promoter impact the magnitude of HO-1 expression profiles. Long GT repeats code for less stable (Z-conformational) DNA with blunted transcriptional activity resulting in lower resting and stimulated HO-1 protein

• It has been reported that CD

  2022-04-07

  

  It has been reported that CD133+ glioma stem Tankyrase Inhibitors 49 australia are resistant to temozolomide (TMZ) therapy [155]. Dose dependent TMZ treatment of CD133+ cells enhanced activities of the Notch and SHh pathways [156]. Moreover, 500 μmol/L TMZ induced a significant upregulation of Gli1

• Of what interest is the link

  2022-04-06

  

  Of what interest is the link between GSNOR and NO in the plant response to Fe deficiency? On the one hand, NO acts as an important signal to help plants accommodate Fe deficiencies; on the other hand, surplus NO is indeed a harmful RNS that induces severe S-nitrosylation-related damage at a higher s

• br Other Functions of HCA Receptors

  2022-04-06

  

  Other Functions of HCA Receptors HCA receptors, in particular HCA1, are expressed in various primary tumor Schaftoside 77, 78, 79. This is of interest, as most solid tumors show increased glucose uptake and lactate formation even under normoxic conditions, with lactate concentrations in the tumor

• br Acknowledgements br Introduction The study methods

  2022-04-06

  

  Acknowledgements Introduction The study methods consisted of the review of articles included in the Pubmed and Medline databases and in the clinicaltrials.gov clinical trials register between 2013 and 2016, and of the preliminary results of therapies presented at international trichology confe

• Based on work from our labs with mGlu NAMs and

  2022-04-06

  

  Based on work from our labs with mGlu NAMs, and the ability of [3.3.0] systems, such as the octahydropyrrolo[3,4-]pyrrole, to effectively mimic piperazines, we focused our attention on the potential bioisoteric replacement of the [3.1.0] system of and , as well as the piperidine of , with a [3.3.0]

• Then the seven complexes GLOI indomethacin

  2022-04-06

  

  Then the seven complexes (GLOI-indomethacin, GLOI-zomepirac, GLOI-fenoprofen, and GLOI-ketoprofen, GLOI-tolmetin GLOI-curcumin, and GLOI-bisdemethoxycurcumin) were energy-minimized to remove unfavorable steric strain relative to the force field adopted. Further MD simulations were carried out based

• br Membrane transporters as a novel

  2022-04-06

  

  Membrane transporters as a novel therapeutic target in pediatric TBI The concept of targeting membrane transporters began with identifying a neuroprotective drug and a corresponding transporter inhibitor. Somewhat serendipitously, we discovered that N-acetylcysteine (NAC), a cysteine donor for GS

• (R,S)-Anatabine ICH induced striatal lesion produced a reduc

  2022-04-06

  

  ICH-induced striatal lesion produced a reduction of EAAT1 expression analogous to the decreased glutamate uptake at 6 h. The combined reduction of excitatory amino (R,S)-Anatabine transporters and of glutamate uptake activity might explain the well-known glutamate excitotoxicity following brain isc

• br Materials and methods br Results br Discussion br Acknowl

  2022-04-06

  

  Materials and methods Results Discussion Acknowledgments Introduction As we move into an aging society, there has been a growing interest in neurological disorders [1]. Neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) cause cognitive malfunction

15212 records 482/1015 page Previous Next First page 上5页 481482483484485 下5页 Last page