• Glucagon was described as an insulin secretagogue as early

  2022-10-03

  

  Glucagon was described as an insulin secretagogue as early as 1965 (Samols et al., 1965). Our studies extend these findings by demonstrating that this is a direct effect mediated by distinct receptors in the mouse pancreas. Previous experiments on isolated β porcn clearly show that glucagon is capa

• br Introduction Glucose homeostasis is

  2022-10-03

  

  Introduction Glucose homeostasis is primarily regulated by the hormones insulin and glucagon, secreted from the pancreatic islets of Langerhans. Although insulin produced by β fiin is the blood glucose-lowering hormone, glucagon secreted from α cells acts as the major counter-regulatory hormone

• br Materials and methods br

  2022-10-03

  

  Materials and methods Results Unitary currents of Gardos N6022 were identified by their conductance value, inward rectification, voltage independence of open probability, kinetics and Ca2+-sensitivity, all features which have been described elsewhere [8], [13], [20], [23], [24], [25], [26]. B

• br Concluding remarks In this small

  2022-10-02

  

  Concluding remarks In this small material of thirteen pituitary tumors of various kinds, we could not run statistical analysis. However, with a follow-up period of up to five years, we show that Disclosure Statement Acknowledgments Introduction Galanin is a 29/30-residue neuropeptide fo

• br Acknowledgments This research was supported in part by Na

  2022-10-02

  

  Acknowledgments This research was supported in part by National Institutes of Health IDeA Program COBRE grant GM110732; a USDA National Institute of Food and Agriculture Hatch project; and the Montana State University Agricultural Experiment Station. Introduction Propofol (2,6-Diisopropylphen

• Conflicting data concerning the involvement

  2022-10-02

  

  Conflicting data concerning the involvement of H2R on glycaemia has also arisen. Its antagonism was reported to decrease [35], not affect [36], [37] and increase [38], [39] NT157 levels. In comparison, the clinical experience with antipsychotic drugs generated clearer evidence for the involvement o

• Diabetes and atherosclerosis are paralleled by impaired woun

  2022-10-02

  

  Diabetes and atherosclerosis are paralleled by impaired wound healing and endothelial angiogenesis in the periphery, which cause severe complications and mainly occur as a result of the elevated circulating levels of glucose and free fatty acids. Yuan et al. recently showed that palmitic o-Phenanthr

• br Materials and methods br Results br Discussion

  2022-10-02

  

  Materials and methods Results Discussion It was previously shown that heterologous DNA vaccines composed of fused cDNA fragments encoding chimeric NH2-terminal human HER2 and COOH-terminal rat neu sequences stimulated stronger antibody responses and protective antitumor immunity than either

• The data presented here support a dynamic

  2022-10-02

  

  The data presented here support a dynamic and complex interplay among labile heme, BACH1 and HO-1. It appears also that metabolites of heme degradation may participate in the mechanistic regulation of the various factors examined. Our results point to the possibility that the HO-1 pathway restricts

• The Y H D A variant

  2022-10-01

  

  The Y56H/D168A variant was resistant to all tested PIs, and the inhibitor binding mode determined the molecular mechanism of resistance. Prior to the development of grazoprevir, PIs typically contained large heterocyclic P2 moieties that strongly interacted with S2-subsite residues (Ali et al., 2013

• TH588 Previous studies showed that pregnancy rate improves w

  2022-10-01

  

  Previous studies showed that pregnancy rate improves when ewes have a BCS that exceeds a minimum threshold [43]. The pregnancy rate is increased in sheep with BCS ≥2.5 [44] and >2 [45]. In this work, pregnancy rate was higher in the GnRH group with low BCS compared to the hCG and Control groups. Des

• Experimental section br Results and

  2022-09-30

  

  Experimental section Results and discussion Conclusion In summary, we have developed a fluoresence method to sensitively detect hAAG on the basis of TdT-activated Endo IV-assisted hyperbranched amplification. This method shows the following advantages: (1) the combination of TdT-mediated exte

• It is becoming increasingly apparent that membrane lipids

  2022-09-30

  

  It is becoming increasingly apparent that membrane lipids play a critical role in modulating and regulating protein function. For example, embedding the homologous SLC1 transporter GltPh in a POPE bilayer allowed a third Na+ binding site to be identified from MD simulations [42], and the binding ene

• br Conclusion br Conflict of interest br Acknowledgments

  2022-09-30

  

  Conclusion Conflict of interest Acknowledgments This work was supported by an NRF grant (2016R1A2B4011196) from the Korea Research Foundation. Introduction Thymic epithelial tumors are rare, but they are the most common primary neoplasm of the thymus and of the anterosuperior mediastinu

• Rifabutin Introduction Erythrocyte membrane proteins or thei

  2022-09-30

  

  Introduction Erythrocyte membrane proteins or their orthologs are found in almost all Rifabutin of the body [1,2]. Because of this compositional similarity and the erythrocyte membrane's accessibility, the red blood cell membrane (RBCM) has served as a crude model for mammalian plasma membranes fo

15213 records 397/1015 page Previous Next First page 上5页 396397398399400 下5页 Last page