• Another interesting finding regarding substrate selectivity

  2019-08-22

  

  Another interesting finding regarding substrate selectivity of iPLA2-VIA in whole cellular systems stems from the observation that some of the major species hydrolyzed by the enzyme contain a 16:1 fatty nigericin at the sn-2 position [57,119], raising the possibility that iPLA2-VIA may constitute a

• br Acknowledgements This work was financially supported by I

  2019-08-22

  

  Acknowledgements This work was financially supported by Industrial Technology Institute, Sri Lanka through funds received from Sri Lankan Government Treasury (TG13/69). G. D. Liyanaarachchi received postgraduate research scholarship grant from National Science Foundation Sri Lanka (NSF/SCH/2017/0

• Recent studies support the concept that

  2019-08-22

  

  Recent studies support the concept that dietary metabolites, such as retinoids and AHR ligands, regulate ILC3 function. These metabolites act through intracellular nuclear receptors that function as transcription factors, thereby controlling ILC activity through the stimulation of specific transcrip

• Our study provides proof of principle

  2019-08-22

  

  Our study provides proof of principle for dimerizing two different E3 ligases as a novel approach to inducing one ligase to degrade the other one. The outcome of ‘ligase versus ligase’ PROTAC-mediated activity might be unpredictable a priori, but could reveal a new mechanism for proximity-mediated h

• br Conclusion AS SP the

  2019-08-22

  

  Conclusion AS+SP, the first-line treatment, still remains highly effective in Pakistan following its introduction in 2007. However, molecular data indicate that SP resistance is being established in Pakistan, although mutations that confer a high risk of SP treatment failure are rare or non-exist

• br Cysteine proteases as molecular targets for trypanosomati

  2019-08-22

  

  Cysteine proteases as molecular targets for trypanosomatid diseases Approaches relying on a molecular target, such as SBDD and target-based screening, have supported outstanding scientific developments in current pharmaceutical R&D. By integrating experimental and computational methods, these str

• br Materials and methods br Results br Discussion In this

  2019-08-21

  

  Materials and methods Results Discussion In this study, we investigated two novel candidate therapeutics, the related CRM1-inhibiting SINEs KPT-185 and KPT-276, in treatment of NHL. The results showed that KPT-185 induced growth inhibition, cell-cycle arrest, and apoptosis in tumor MTT in

• In contrast to PEGylated proteins which tend to have

  2019-08-21

  

  In contrast to PEGylated proteins which tend to have reduced nuclear receptor in the body relative to their native counterparts, proteins conjugated to albumin tend to accumulate in certain locales in vivo. This means that albumin-based drug carrier systems have particular applications in the field

• Several highly selective COX inhibitors

  2019-08-21

  

  Several highly selective COX-2 inhibitors (coxibs) have been reported and marketed [6], including celecoxib [7] and etoricoxib [8] (Fig. 1). Even though these drugs produce less ulceration than conventional NSAIDs, coxibs still produce significant gastric and cardiovascular side effects due to the d

• br Acknowledgements br Introduction Protein tyrosine phospho

  2019-08-21

  

  Acknowledgements Introduction Protein–tyrosine phosphorylation, catalyzed by protein–tyrosine kinases and protein–tyrosine phosphatases, has a pivotal role in the regulation of a wide variety of cellular processes. Similar numbers of tyrosine kinases and tyrosine phosphatases are encoded by th

• br Other pathways involved in the preventive

  2019-08-21

  

  Other pathways involved in the preventive and therapeutic potential of flavonoids in neurodegenerative diseases Rather than the induction of MAPK/ERK pathway, flavonoids actively modulate other critical intracellular neuronal survival and death protein kinases pathways, more importantly PI3K/Akt,

• atr inhibitor The contribution of local ETA and

  2019-08-21

  

  The contribution of local ETA and ETB receptors towards heat hyperalgesia induced by inoculation of XC tumor atr inhibitor in the paw of mice has been demonstrated by Baamonde and colleagues (Baamonde et al., 2004). Furthermore, using neuropathic and inflammatory nociception models, several studies

• Most remarkably an essentially identical collagen binding mo

  2019-08-21

  

  Most remarkably, an essentially identical collagen-binding mode to DDR2 is employed by SPARC, an α-helical matricellular protein unrelated to DDR2 that also recognizes the GVMGFO motif in collagen (Giudici et al., 2008, Hohenester et al., 2008). The convergence of binding mechanisms suggests that th

• br Results br Discussion Many studies have shown that intrin

  2019-08-21

  

  Results Discussion Many studies have shown that intrinsic properties of the E2 enzyme govern the nature of the Ub modification, including both the multiplicity of the Ub modification and the specific isrib type in the case of polyubiquitin chains [3], [4], [9], [14]. Whereas previous studies

• Darunavir Ethanolate DAPK is a kD Ca calmodulin

  2019-08-21

  

  DAPK is a 160-kD Ca2+/calmodulin (CaM)-regulated Ser/Thr kinase that mediates cell death. The activated forms of DAPK and DRP-1 are capable of inducing two distinct cytoplasmic events characteristic of programmed cell death, including membrane blebbing and the formation of autophagic vesicles (Inbal

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